LOSS OF MFN1 BUT NOT MFN2 ENHANCES ADIPOGENESIS.

Loss of Mfn1 but not Mfn2 enhances adipogenesis.

ObjectiveA biallelic missense mutation in mitofusin 2 (MFN2) causes multiple symmetric lipomatosis and partial lipodystrophy, implicating disruption of mitochondrial fusion or interaction with other organelles in adipocyte differentiation, growth and/or survival.In this study, we aimed to document the impact of loss of Notebooks mitofusin 1 (Mfn1)

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Trifunctional antibody-cytokine fusion protein formats for tumor-targeted combination of IL-15 with IL-7 or IL-21

Cytokines from the common gamma chain receptor family, such as IL-15, IL-21 and IL-7, show promise for cancer immunotherapy and have been incorporated individually into the immunocytokine approach.However, their efficacy as monotherapy is limited.Here, we investigated the molecular design of tumor-directed trifunctional antibody-cytokine fusion pro

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ORGANIZATIONAL CITIZENSHIP BEHAVIOR DITINJAU DARI KECERDASAN EMOSIONAL DAN PERCEIVED ORGANIZATIONAL SUPPORT PADA KARYAWAN PT. X

Penelitian ini bertujuan untuk mengetahui secara empirik hubungan Kecerdasan Emosional dan Perceived Organizational Support (POS) dengan Organizational Citizenship Behavior (OCB) pada karyawan PT.X.Hipotesis yang diajukan dalam penelitian ini adalah bahwa ada Notebooks hubungan positif antara Kecerdasan Emosional dengan OCB, selanjutnya ada hubunga

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