Loss of Mfn1 but not Mfn2 enhances adipogenesis.
ObjectiveA biallelic missense mutation in mitofusin 2 (MFN2) causes multiple symmetric lipomatosis and partial lipodystrophy, implicating disruption of mitochondrial fusion or interaction with other organelles in adipocyte differentiation, growth and/or survival.In this study, we aimed to document the impact of loss of Notebooks mitofusin 1 (Mfn1)